On September 15, 2025, actor Eric Dane appeared in a heartfelt Instagram video supporting the I Am ALS organization, where he spoke openly about his life with Amyotrophic Lateral Sclerosis (ALS). Wearing a navy blue “I Am ALS” T-shirt, Dane delivered a calm but urgent message about the importance of raising funds through the “Push for Progress” campaign, which aims to accelerate research, expand treatment options, and improve care for people living with ALS.

Fans quickly noticed changes in his speech and physical condition, expressing concern over his “slurred” speech and visible muscle twitching. Many took to social media to share their heartbreak and questions about the progression of his illness. This video came shortly after Dane’s surprising absence from the 2025 Emmy Awards, where he was scheduled to appear alongside Grey’s Anatomy co-star Jesse Williams to celebrate the show’s 20th anniversary but withdrew without explanation, causing the tribute to be canceled.

Eric Dane publicly announced his ALS diagnosis in April 2025, revealing that the disease had already started affecting his mobility and speech. In a deeply emotional interview with Diane Sawyer, he shared the early signs he experienced, such as weakness in his right hand, and the difficult journey to receive the diagnosis. He spoke candidly about the physical and emotional impact ALS has had on him and his family, including a touching story about how his youngest daughter saved him during a recent boat trip when he was no longer able to swim.

Despite these challenges, Dane remains determined to live fully and continue working. He expressed gratitude for the support of his wife, actress Rebecca Gayheart, and their teenage daughters, crediting them as his biggest source of strength.

Dane emphasized that while ALS has changed his life, it will not define or silence him. “I don’t think this is the end of my story. I’m fighting as much as I can,” he said.

He also highlighted the importance of the “Push for Progress” campaign, calling on viewers to join the effort to raise $1 billion in three years to fund research and improve treatment access. Dane’s video and openness have inspired many fans and people living with ALS worldwide, turning him from a beloved TV heartthrob into a powerful symbol of courage, resilience, and hope.